How much weight can I expect to lose on semaglutide?
Most patients lose 10-15% of body weight over 12-month treatment, equating to 35-50 lbs for a 300 lb individual. Some lose as much as 20% body weight.
Does semaglutide have long-term safety risks?
No increased cardiovascular risks observed, but a slight increased risk of diabetic retinopathy progression and no medullary thyroid cancer risk. Still being closely monitored as a newer medication.
What happens when I stop semaglutide injections?
Weight regain is common, but the average regain is around 30% of lost weight. Making lasting lifestyle changes while on treatment reduces relapse.
Can semaglutide be used long-term?
Although originally approved for 68 weeks, recent 5-year data shows excellent safety, and many experts now use it beyond 1 year, especially if weight loss has plateaued on the maximal dose.
Table: Common Pros and Cons of Semaglutide Treatment
Pros |
Cons |
Exceptional weight loss: 10-15% total body weight |
Temporary GI side effects: nausea, vomiting, diarrhea |
Improves heart health: ↓26% CV event risk |
Injected medication - needles |
Treats root of obesity: alters hormones regulating appetite/weight |
Requires prior authorization & check-ins with doctor |
Also lowers blood sugar: HbA1c drops 1-2% |
Potential small blood sugar drops |
Well-tolerated by most patients |
Unknown long-term use risks (>5 years) |